Soctec is a versatile extended release gastro-retentive platform technology that has been designed to overcome many of the limitations of alternative systems.

Why is gastro-retention important?

The oral route of administration is preferred for the majority of drugs, owing to its flexibility, ease of administration and patient compliance. However, many drugs are preferentially absorbed in the upper gastro-intestinal tract. In order to target this "absorption window" it is often desirable to retain the drug delivery system in the stomach for an extended period of time so that the drug can be released slowly and so be absorbed more efficiently in the upper intestine.

How Soctec™ works

Soctec is an easy to swallow elongated capsule. It has an integral buoyancy chamber and a counter-balanced denser ballast, to ensure that it floats upright in the stomach fluids as soon as it is swallowed.

Soctec Labelled Areas

Normally the contents of the stomach are crushed by peristaltic contractions and the contents are rapidly expelled through the pylorus into the duodenum. However, owing to its shape and physical properties Soctec could be retained in the stomach for more than 9 hours. During this time Soctec releases its drug load at a pre-determined rate, allowing absorption in the small intestine upper segments.

Soctec Floating In Stomach

Applications for Soctec™

Soctec can be used with a range of drugs that have a narrow absorption window and are preferentially absorbed in the upper intestine segments. It can also improve the bioavailability of drugs that are degraded by the alkaline pH of the lower gastro-intestinal tract. It is also suitable for drugs that are targeted for local action in the stomach and small intestine.

Benefits of Soctec™

Soctec is easy to swallow, allowing it to quickly enter the stomach where it starts to deliver its drug load. As a result of its in-built buoyancy and its elongated shape it could be retained in the stomach for more than 9 hours, providing an extended period for drug release without disturbing normal food transit. Soctec is very adaptable and can be used with drugs having different physicochemical and therapeutic characteristics. The drug release profile can be tailored to the drug’s absorption characteristics and the clinical need. Soctec utilizes conventional manufacturing techniques facilitating rapid and cost-effective industrialization.

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