Oral drug bioavailability enhancers

Skyepharma has a range of oral drug bioavailability enhancers that use proprietary technologies that act by improving solubility.

Solubility is an essential factor for drug effectiveness, independent of administration route. It is also a major challenge for pharmaceutical companies developing new products, since nearly half of all new chemically-derived drugs are poorly soluble. Therefore many promising compounds never reach the market or are developed in a sub-optimal formulation, providing low or unpredictable bioavailability or posing an increased risk of side effects.

How Skyepharma’s drug bioavailability enhancers work

Skyepharma’s Insoluble Drug Delivery (IDD®) platform comprises a number of major enabling technologies to address solubility issues. The IDD® technologies use microparticles, microdroplets and phospholipids or other surface modifiers to support improved solubility. All excipients used are approved by the US FDA.

Skyepharma also has a medicated chewing gum that can be used to improve bioavailability by solubilisation in saliva prior to swallowing.

Benefits of Skyepharma’s drug bioavailability technologies

Skyepharma’s drug bioavailability technologies allow solid oral products to be developed as alternatives to intravenous or ophthalmic formulations of drugs that are currently only available in less desirable forms. The technologies offer the following potential benefits:

  • Improved oral bioavailability
  • Formulations with lower toxicity
  • Rapid onset of action
  • Suitability for high drug payloads
  • Sustained-release depot formulations
  • Suitability across various dosage forms, including oral, topical and pulmonary
  • Applicability to all therapeutic classes, for example including anaesthetics, anti-cancer agents and immune-suppressants

Products incorporating the technology

Our IDD® technology is currently available in Triglide® that is marketed in the US.

Contact us to find out how we can help with your oral drug delivery project.

Triglide was developed by Skyepharma using its IDD technology

Copyright 2014, Skyepharma. All Rights Reserved. Skyepharma PLC is a public limited company registered in England and Wales, registration number 0107582.
Registered office: 46-48 Grosvenor Gardens, London SW1W 0EB, United Kingdom

Contact addresses

Skyepharma PLC
46-48 Grosvenor Gardens
London
SW1W 0EB
UK

Tel: +44 207 881 0524

Fax: +44 207 881 1199

E-mail us

Skyepharma AG
Eptingerstrasse 61
4132 Muttenz
Switzerland

Tel: +41 61 467 5555

Fax: +41 61 467 5500

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