Geomatrix™

The Geomatrix™ technology is applied to achieve customised levels of controlled release of specific drugs and can achieve simultaneous release of two different drugs and different rates from a single tablet.

The controlled release is achieved by constructing a multilayered tablet made of two basic key components; 1) hydrophilic polymers such as hydroxypropyl methycellulose (HPMC) and 2) surface controlling barrier layers. Active loaded core surface that is available for drug release when exposed to the fluid is controlled by barrier layers.

The combination of layers, each with different rates of swelling, gelling and erosion, is responsible for the rate of drug release within the body. When first swallowed, for example, the drug concentration is high but the surface area low. As time progresses the core swells and the surface area increases to compensate for the decrease in drug concentration.

One of the major benefits of the Geomatrix™ technology is its ability to be easily incorporated into the production line. The Geomatrix™ tablets can be manufactured by readily available equipment that can be integrated into widely-used pharmaceutical processes, thus giving firms more control over their own production activities.

Other advantages of the Geomatrix™ technology are:

Reproducibility
Efficacy
Versatility of release control mechanisms
Controlled release of poorly soluble drugs
Timed release of drugs
Bi-phasic release of drugs
Release of 2 or more drugs at different rates
Pulsed release of drugs
Safety of use

SkyePharma manufactures several Geomatrix™ products for its partners, which include Sular® for Sciele, ZYFLO CR™ for Critical Therapeutics, Coruno® for Therabel, diclofenac-ratiopharm® uno for ratiopharm and Madopar DR® for Roche.

SkyePharma also produces bio-batches at small scale in a dedicated pilot plant or at industrial scale for collaborative partners.

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SkyePharma PLC is a public limited company registered in England and Wales, registration number 0107582.
Registered office: 46-48 Grosvenor Gardens, London SW1W 0EB, United Kingdom