Geomatrix: customisable oral drug delivery platform

Geomatrix™ is a well-established, validated and customisable oral drug delivery platform technology that is currently used in 8 products that are available in over 80 countries. Geomatrix™ is highly versatile and can be applied to a wide range of different drugs to achieve a variety of different release profiles. It uses well-established ingredients and is easily manufactured using conventional production equipment.

Skyepharma's Geomatrix, a customisable platform oral drug delivery technology

How Geomatrix™ works

Modulation of the drug release profile is achieved by using a multi-layered tablet that combines two key features:

  • Use of highly swellable hydrophilic polymers (e.g. HPMC)
  • Dynamic control of the surface of the layer containing the drug that is exposed to surrounding fluids

The combination of layers, each with different rates of swelling, gelling and erosion, controls the drug release rate within the body. When swallowed the Geomatrix™ system limits the amount of drug released by controlling the surface of the drug-containing layer exposed to fluids. As time progresses the core swells and the surface area increases to compensate for the decrease in drug concentration. The characteristics of Geomatrix™ can be adjusted very flexibly and reproducibly to the desired release properties.

Chart showing Geomatrix oral drug delivery technology

Benefits of Geomatrix™

Geomatrix™ is a highly versatile platform that can be used to create a wide variety of different release profiles. Examples of the application of Geomatrix™ include:

  • A wide range of release profiles
  • Controlled release of both poorly and highly soluble drugs
  • Zero order and bi-phasic release of drugs (either rapid then slow or ascending profiles)
  • Release of two or more drugs at different rates
  • Simultaneous or phased release of several drugs at individualised release rates from a single tablet

Geomatrix™ is currently used in 8 products that are available in over 80 countries. It uses widely approved GRAS (Generally Recognised as Safe) inert ingredients and is easily manufactured using conventional production equipment.

Products incorporating Geomatrix™

Geomatrix™ technology is used in 8 different products sold in more than 80 different countries, including:

Madopar DR, Paxil CR, Requip Once-a-day, Xatral/ Uroxatral, Sular, Zyflo CR, Coruno and Diclofenac-ratiopharm uno;

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Contact us to find out how we can help with your oral drug delivery project.

Copyright 2014, Skyepharma. All Rights Reserved. Skyepharma PLC is a public limited company registered in England and Wales, registration number 0107582.
Registered office: 46-48 Grosvenor Gardens, London SW1W 0EB, United Kingdom

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Skyepharma PLC
46-48 Grosvenor Gardens
London
SW1W 0EB
UK

Tel: +44 207 881 0524

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Skyepharma AG
Eptingerstrasse 61
4132 Muttenz
Switzerland

Tel: +41 61 467 5555

Fax: +41 61 467 5500

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